반응 #1265350

반응 방정식

Oxalyl chloride

2-[2-(2-methoxy-ethoxy)ethoxy]-acetic acid

pyridine

→

CH3(OCH2CH2)2CH2OCH2COCl

용매

toluene

반응 조건

후처리

1. 1
   농축The reaction solution was concentrated in vacuo

실험 절차

Oxalyl chloride (100 g, 0.78 mol) was added dropwise over 1 h to a solution of 2-[2-(2-methoxy-ethoxy)ethoxy]-acetic acid (90 mL, 0.59 mol) and pyridine (0.1 mL, 1 mmol) in anhydrous toluene (250 mL) and the resulting solution was stirred at ambient temperature for 48 h. The reaction solution was concentrated in vacuo to afford CH3(OCH2CH2)2CH2OCH2COCl as a slightly yellow oil (120 g, 96%). This compound was used without any further purification.

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