반응 #1265

반응 방정식

ethyl 5-nitrobenzofuran-2-carboxylate

→

ethyl 5-aminobenzofuran-2-carboxylate

용매

methanol

반응 조건

후처리

1. 1
   여과The catalyst is filtered off
2. 2
   농축the solution is concentrated

실험 절차

A solution of 2.3 g of ethyl 5-nitrobenzofuran-2-carboxylate in 60 ml of methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After customary working up, ethyl 5-aminobenzofuran-2-carboxylate, Rf 0.1 (dichloromethane/ethanol 9.5:0.5) obtained; hydrochloride m.p. 246°-248°.

출처