반응 #1256734

반응 방정식

[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile

di-terbutyl carbonate

Sodium borohydride

→

tert-butyl {2-[1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]ethyl}carbamate

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONis added portionwise to the reaction mixture
2. 2
   기타is allowed to room temperature

실험 절차

The [1-methyl-4-(trifluoromethyl)-1H-pyrazol-3-yl]acetonitrile (4.76 mmol, 0.90 g), the di-terbutyl carbonate (9.52 mmol, 2.08 g) and nickel chloride hexahydrate (4.77 mmol, 1.13 g) are added to methanol (10 ml) at room temperature. Sodium borohydride (13.1 mmol, 0.49 g). is added portionwise to the reaction mixture. The reaction mixture is allowed to room temperature and stirred for three hours.

출처