반응 #1253196

반응 방정식

3-Fluoro-4-(4-{2-fluoroethyl}-3-oxopiperazin-1-yl)nitrobenzene

→

5-amino-2-[4-(2-fluoroethyl)-3-oxopiperazin-1-yl]fluorobenzene

용매

ethyl acetate

DMF

반응 조건

후처리

1. 1
   기타the solution flushed with argon
2. 2
   workup.ADDITIONPalladium (10% on carbon, 200 mg) is added
3. 3
   여과the mixture is filtered through celite and solvent
4. 4
   기타removed
5. 5
   세척washed twice with water
6. 6
   건조dried over magnesium sulfate
7. 7
   기타the solvent is removed

실험 절차

3-Fluoro-4-(4-{2-fluoroethyl}-3-oxopiperazin-1-yl)nitrobenzene (4.35 g) is dissolved in a mixture of ethyl acetate (250 ml) and DMF (5 ml), and the solution flushed with argon. Palladium (10% on carbon, 200 mg) is added and the mixture hydrogenated under ambient pressure. After gas uptake had ceased, the mixture is filtered through celite and solvent removed. The residue is taken up in ethyl acetate, washed twice with water, dried over magnesium sulfate and the solvent is removed to give 5-amino-2-[4-(2-fluoroethyl)-3-oxopiperazin-1-yl]fluorobenzene which is used without further purification.

출처