반응 #1253193

반응 방정식

lauryl alcohol

triethyl amine

p-toluene sulphonyl chloride

→

lauryl tosylate

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   세척The reaction mixture was then washed with 20% sodium chloride solution (500 ml)
2. 2
   건조The washed organic layer was dried over anhydrous sodium sulphate
3. 3
   기타Removal of solvent under vacuo
4. 4
   기타resulted in colorless oil that

실험 절차

To a stirred and a cooled solution of lauryl alcohol (186.0 g, 1.0 mole) and triethyl amine (121.0 g, 1.2 mole) in dichloromethane (600 ml), p-toluene sulphonyl chloride (228.0 g, 1.2 mole) in dichloromethane (400 ml) was slowly added and the reaction was continued at room temperature for 10 hours. The reaction mixture was then washed with 20% sodium chloride solution (500 ml). The washed organic layer was dried over anhydrous sodium sulphate. Removal of solvent under vacuo resulted in colorless oil that solidified on keeping to yield lauryl tosylate. (309.0 g, 91%), m. p. 29° C. (literature m. p. 29° C.).

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