반응 #1245

반응 방정식

( 17 )

2-amino-4'-fluorobenzophenone

4-fluoroacetophenone

toluene sulfonic acid monohydrate

→

2,4-bis(4-fluorophenyl)quinoline

용매

water

반응 조건

후처리

1. 1
   기타removed
2. 2
   온도the mixture is cooled
3. 3
   기타the crude solid product is crushed
4. 4
   세척washed with hot ethanol The product
5. 5
   기타is further recrystallized from toluene

실험 절차

A flask is loaded with (17) (21.5 g, 0.1 mol), 4-fluoroacetophenone (13.8 g, 0.1 mol), and toluene sulfonic acid monohydrate (3.8 g, 0.02 mol). The flask is heated to 200° C. and the water of condensation removed. After water evolution ceased, the mixture is cooled and the crude solid product is crushed and washed with hot ethanol The product is further recrystallized from toluene.

출처