반응 #1244284

반응 방정식

sodium hydroxide

(S)-1,4-bis(methanesulfonyloxy)pentane

benzylamine

→

(R)-1-benzyl-2-methylpyrrolidine

수율 100.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   추출an extraction
2. 2
   농축The organic layer was concentrated under a reduced pressure
3. 3
   기타to obtain a yellow oily substance
4. 4
   기타This product was purified by silica gel column chromatography

실험 절차

First, 2.49 g (9.6 mmol) of (S)-1,4-bis(methanesulfonyloxy)pentane produced in Example 5 and 5.13 g (47.9 mmol) of benzylamine were stirred at 70° C. for three hours. Subsequently, 30 mL of ethyl acetate and 4.0 g of a 20 weight percent aqueous solution of sodium hydroxide were added to the mixture to perform an extraction. The organic layer was concentrated under a reduced pressure to obtain a yellow oily substance. This product was purified by silica gel column chromatography. Thus, (R)-1-benzyl-2-methylpyrrolidine was obtained as a light yellow oily substance (1.83 g, yield: 100%).

출처