반응 #1244252

반응 방정식

triethyl amine

Tetraethylene glycol

TBDMSCl

→

5c

수율 42.0%

2-(2-{2-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxy)-ethanol

수율 42.0%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타After standard workup with dichloromethane, the residue was purified by silica gel column chromatography (50% ethyl acetate in hexane)

실험 절차

Tetraethylene glycol, 4c (1.12 g, 5.77 mmol) and TBDMSCl (0.87 g, 5.77 mmol) were dissolved in dichloromethane (25 ml) followed by triethyl amine (1.46 g, 14.4 mmol). The solution was stirred at room temperature for 2 hours. After standard workup with dichloromethane, the residue was purified by silica gel column chromatography (50% ethyl acetate in hexane) to afford 5c (744 mg, 42%): 1H NMR δ 3.66 (m, 16H), 2.51 (t, 1H, J=5.86 Hz), 0.89 (s, 9H), 0.07 (s, 6H).

출처