반응 #1244

반응 방정식

( 16 )

3-(4-fluorophenyl)-2,1-benzisoxazole

→

2-amino-4'-fluorobenzophenone

용매

tetrahydrofuran

triethylamine

반응 조건

후처리

1. 1
   기타The vigorously stirred suspension is flushed with hydrogen gas
2. 2
   기타8-10 hours
3. 3
   기타The catalyst is removed by filtration through a bed of celite
4. 4
   기타the solvent is removed under reduced pressure
5. 5
   기타The product (16) is recrystallized from toluene

실험 절차

To a suspension of (16) (42.6 g, 0.2 mol) in 750 ml of dry tetrahydrofuran (THF) and 20 ml of triethylamine is added 5% palladium on charcoal (6 g). The vigorously stirred suspension is flushed with hydrogen gas and stirred at room temperature under a hydrogen atmosphere until absorption of hydrogen ceases (approximately 90-90% of the molar amount; 8-10 hours). The catalyst is removed by filtration through a bed of celite, and the solvent is removed under reduced pressure. The product (16) is recrystallized from toluene.

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