반응 #1243044

반응 방정식

2-amino-5-phenyl-3-thiophenecarboxylic acid, ethyl ester

6-chloro-3-pyridinecarboxylic acid

→

4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno-[2,3-d]pyrimidine-7-carboxylic acid

수율 6.2%

반응 조건

실험 절차

From 5.0 g (0.02 mol) of 2-amino-5-phenyl-3-thiophenecarboxylic acid, ethyl ester (Chemische Berichte, Vol. 99, pages 94-100, 1966) and 3.2 g (0.02 mol) of 6-chloro-3-pyridinecarboxylic acid (Aldrich Chemical Company), following the procedure of Example 3, there is obtained 0.4 g of 4-oxo-2-phenyl-4H-pyrido[1,2-a]thieno-[2,3-d]pyrimidine-7-carboxylic acid; mp 387°-392° C. after recrystallization from pyridine.

출처