반응 #1242822

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Oxygen

N-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)acetamide

isobutyric acid

→

title compound

수율 37.0%

N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)-acetamide

수율 37.0%

용매

water

반응 조건

후처리

1. 1
   기타fitted with a condenser
2. 2
   기타The dark brown mixture is oxygenated for 100 minutes at room temperature
3. 3
   기타10 minutes
4. 4
   기타is reheated to 50° C.
5. 5
   기타the flow of oxygen is terminated 2 hours later

실험 절차

Oxygen is passed into a mixture of N-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)acetamide (1.0 g; 5.13 m mole), cobaltous acetate (0.25 g; 1.4 m mole), cobaltous bromide tetrahydrate (0.32 g; 1.1 m mole), isobutyric acid (20 ml) and water (0.2 ml) in a sintered glass funnel fitted with a condenser and thermometer, via the stem of the funnel. The dark brown mixture is oxygenated for 100 minutes at room temperature, then heated briefly to 48° C. After 2 hours and 10 minutes, the mixture is reheated to 50° C. and the flow of oxygen is terminated 2 hours later. The mixture is then worked up as described in Example 1 to attain a 37% yield of the title compound.

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