반응 #1227

반응 방정식

water

sodium hydride

methyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate

iodomethane

→

methyl 2-methoxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate

용매

DMF

DMF

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for two hours
2. 2
   추출extracted with ethyl ether
3. 3
   기타the organic phase decanted
4. 4
   건조dried over magnesium sulfate
5. 5
   기타evaporated
6. 6
   기타1.6 g (96%) of the expected compound was recovered in the form of a colorless oil

실험 절차

130 mg (4.2 mmol) of sodium hydride (80% in oil) and 20 ml of DMF were introduced into a three-necked flask, a solution of 1.6 g (4.2 mmol) of methyl 2-hydroxy-4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-anthryl)benzoate in 50 ml of DMF was added dropwise and the mixture was stirred until gaseous emission ceased. 340 μl (5.5 mmol) of iodomethane were then added and the mixture was stirred at room temperature for two hours. The reaction medium was poured into water, extracted with ethyl ether, the organic phase decanted, dried over magnesium sulfate and evaporated. 1.6 g (96%) of the expected compound was recovered in the form of a colorless oil.

출처