반응 #1224

반응 방정식

4-iodo-2-trichloroacetylpyrrole

methanol

sodium methoxide

→

methyl 4-iodo-2-pyrrolecarboxylate

용매

water

ethyl ether

반응 조건

후처리

1. 1
   기타the reaction medium evaporated to dryness
2. 2
   기타the residue obtained
3. 3
   기타The organic phase was decanted off
4. 4
   건조dried over magnesium sulfate
5. 5
   기타evaporated
6. 6
   기타The residue obtained
7. 7
   기타was triturated in heptane
8. 8
   여과filtered
9. 9
   기타4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered

실험 절차

8.2 g (24 mmol) of 4-iodo-2-trichloroacetylpyrrole and 100 ml of methanol were introduced into a round-bottomed flask and 2 g (36 mmol) of sodium methoxide were added. The mixture was stirred at room temperature for four hours, the reaction medium evaporated to dryness, and the residue obtained taken up in water and ethyl ether. The organic phase was decanted off, dried over magnesium sulfate and evaporated. The residue obtained was triturated in heptane and filtered; 4.9 g (81%) of the expected ester of melting point 77°-78° C. were recovered.

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