반응 #1223

반응 방정식

potassium carbonate

trichloroacetyl chloride

pyrrole

→

2-trichloroacetylpyrrole

용매

water

ethyl ether

ethyl ether

반응 조건

후처리

1. 1
   기타The organic phase was decanted off
2. 2
   건조dried over magnesium sulfate
3. 3
   기타evaporated
4. 4
   기타the residue triturated in hexane
5. 5
   여과filtered
6. 6
   기타42.7 g (87%) of the expected compound of melting point 78°-79° C. were recovered

실험 절차

45 g (247 mmol) of trichloroacetyl chloride and 100 ml of ethyl ether were introduced into a three-necked flask. A solution of 15.4 g (230 mmol) of pyrrole in 100 ml of ethyl ether was added dropwise and the mixture was stirred at room temperature for one hour, then a solution of 20 g of potassium carbonate in 60 ml of water was added slowly. The organic phase was decanted off, dried over magnesium sulfate, evaporated, the residue triturated in hexane and filtered. 42.7 g (87%) of the expected compound of melting point 78°-79° C. were recovered.

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