반응 #1209

반응 방정식

1,2-epoxy-16-hexadecanol

ethanolamine

N2

ethanolamine

→

title compound

수율 68.0%

1-(2-hydroxyethylamino)-2,16-hexadecanediol

수율 68.0%

용매

ethanol

ethanol

ethanol

반응 조건

후처리

1. 1
   기타A 50-ml two-necked flask equipped with a stirrer
2. 2
   온도While heating
3. 3
   workup.DISTILLATIONwere distilled off under reduced pressure
4. 4
   기타the resultant residue was purified by flash column chromatography on silica gel

실험 절차

A 50-ml two-necked flask equipped with a stirrer, dropping funnel and N2 inlet tube was charged with 4.14 g (68 mmol) of ethanolamine and 0.8 g of ethanol. While heating and stirring the mixture at 80° C. in an N2 atmosphere, an ethanol solution of 0.87 g (3.4 mmol) of 1,2-epoxy-16-hexadecanol was added dropwise over 1.5 hours. The resultant mixture was stirred further for 2 hours at 80° C. After completion of the reaction, ethanol and excess ethanolamine were distilled off under reduced pressure, and the resultant residue was purified by flash column chromatography on silica gel, thereby obtaining 0.72 g (yield: 68%) of the title compound (IId-1).

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