반응 #12069

반응 방정식

4-vinyl benzylchloride

dimethylsulfoxide

potassium cyanide

→

4-vinylbenzylcyanide

용매

water

반응 조건

후처리

1. 1
   추출extracted several times with ethyl acetate
2. 2
   세척The combined organic layers were washed with brine
3. 3
   농축concentrated under vacuum
4. 4
   기타The crude red oil was purified by column chromatography on silica gel using 7/93 ethyl acetate/hexane

실험 절차

A mixture of 22.2 g 4-vinyl benzylchloride (0.131 mol), 60 mL dimethylsulfoxide, and 12.8 g potassium cyanide (0.196 mol) was stirred at room temperature for 17 hours. The mixture was poured into 500 mL water and extracted several times with ethyl acetate. The combined organic layers were washed with brine and concentrated under vacuum. The crude red oil was purified by column chromatography on silica gel using 7/93 ethyl acetate/hexane to give 4-vinylbenzylcyanide, a yellow oil (18.03 g, 96%).

출처