반응 #12064

반응 방정식

2-(4-fluorophenylmethyl)indene

butyl lithium

N-(1,1-dimethylethyl)dimethylsilanamine chloride

→

yellow oil

수율 97.0%

(2-(4-fluorophenylmethyl)inden-1-yl)-N-(1,1-dimethylethyl)dimethylsilanamine

수율 97.0%

용매

반응 조건

후처리

1. 1
   기타the mother liquor decanted
2. 2
   workup.DISSOLUTIONthe solid dissolved in THF
3. 3
   온도the reaction heated
4. 4
   온도at reflux for three hours
5. 5
   기타The volatiles were removed in vacuo
6. 6
   추출the residue extracted with hexane
7. 7
   여과filtered
8. 8
   기타the volatiles removed in vacuo

실험 절차

To a mixture of 2-(4-fluorophenylmethyl)indene (2.21 g, 9.9 mmol) in 45 mL of hexanes were added 6.5 mL of butyl lithium (1.6 M hexane; 10.4 mmol). The mixture was stirred overnight, the mother liquor decanted and the solid dissolved in THF. To this was added N-(1,1-dimethylethyl)dimethylsilanamine chloride (1.80 g, 10.8 mmol) and the reaction heated at reflux for three hours. The volatiles were removed in vacuo, the residue extracted with hexane, filtered and the volatiles removed in vacuo to give 3.39 g (97 percent) of a yellow oil.

출처