반응 #1206

반응 방정식

ethanolamine

1-tetradecyloxy-3-methyl-2-butene oxide

→

title compound

수율 58.0%

3-(2-hydroxyethylamino)-4-tetradecyloxy-2-methyl-2-butanol

수율 58.0%

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   기타A 100-ml two-necked flask equipped with a stirrer and a dropping funnel
2. 2
   온도While heating
3. 3
   온도After heating
4. 4
   workup.STIRRINGstirring the mixture further for 16 hours
5. 5
   기타the resultant reaction mixture
6. 6
   농축was concentrated under reduced pressure
7. 7
   기타the resultant residue was purified by column chromatography on silica gel

실험 절차

A 100-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 15.3 g (16.7 mmol) of ethanolamine and 5.0 g of ethanol. While heating and stirring the mixture at 80° C. in a nitrogen atmosphere, an ethanol solution of 5.00 g (16.7 mmol) of 1-tetradecyloxy-3-methyl-2-butene oxide was added dropwise over 3 hours. After heating and stirring the mixture further for 16 hours, the resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 3.47 g (yield: 58%) of the title compound (IIc-4).

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