반응 #12059
ord-1c7e89d4d4514972a067ddc65a248326
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타This was capped with a Dean-Stark trap
- 2온도heated
- 3온도to reflux for two hours at which time the system
- 4기타the volatiles removed in vacuo
- 5기타to leave a dark oil
- 6세척eluted through a silica pad
- 7기타Removal of the volatiles in vacuo
실험 절차
A 500 mL flask was charged with 25.5 g (120 mmol) of trans-2-bromo-1-indanol, 1 g of toluenesulfonic acid and 350 mL of toluene. This was capped with a Dean-Stark trap and heated to reflux for two hours at which time the system was cooled to room temperature and the volatiles removed in vacuo to leave a dark oil. The residue was taken up into hexanes and eluted through a silica pad using hexanes. Removal of the volatiles in vacuo gave 22.5 g (96 percent) of a light yellow oil.