반응 #12025

ord-03aca9a6eb014e909cc8f2829b9f72fc

반응 방정식

C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(Br)nc3N21
intermediate b
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(Br)nc3N21
(4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
C[C@@H]1CN(C(=O)OC(C)(C)C)Cc2cc3cccnc3n21
(R)-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
[BH3-]C#N.[Na+]
sodium cyano borohydride
→
C[C@@H]1CN(C(=O)OC(C)(C)C)CC2Cc3cccnc3N21
(R)-4-Methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

반응물

C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(Br)nc3N21
intermediate b
C[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]2Cc3ccc(Br)nc3N21
(4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
C[C@@H]1CN(C(=O)OC(C)(C)C)Cc2cc3cccnc3n21
(R)-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester
[BH3-]C#N.[Na+]
sodium cyano borohydride

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

This compound was prepared in analogy to Example 2 intermediate b), from (R)-4-methyl-3,4-dihydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester and sodium cyano borohydride.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07098337B2uspto-grants-2006_08