반응 #1200

반응 방정식

tetradecyl glycidyl ether

3-amino-1-propanol

→

title compound

수율 135.0%

1-(3-hydroxypropylamino)-3-tetradecyloxy-2-propanol

수율 135.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타A 300-ml two-necked flask equipped with a stirrer and a dropping funnel
2. 2
   온도the contents were heated
3. 3
   workup.STIRRINGstirred for 1 hour
4. 4
   기타Crystals formed
5. 5
   여과were then collected by filtration
6. 6
   기타recrystallized from methanol

실험 절차

A 300-ml two-necked flask equipped with a stirrer and a dropping funnel was charged with 25.1 g (0.33 mol) of 3-amino-1-propanol and 6.00 g of ethanol, and the contents were heated and stirred at 80° C. in a nitrogen atmosphere. After 9.00 g (33 mmol) of tetradecyl glycidyl ether were added dropwise over 2 hours, the resultant mixture was stirred further for 1 hour. The reaction mixture was poured into 400 ml of ice water and stirred for 1 hour. Crystals formed were then collected by filtration and recrystallized from methanol, thereby obtaining 15.4 g (yield: 92%) of the title compound (IIa-5).

출처