반응 #1199

반응 방정식

ethanolamine

1,2-epoxy-2-methyl-3-tetradecyloxypropane

→

title compound

수율 68.0%

1-(2-hydroxyethylamino)-2-methyl-3-tetradecyloxy-2-propanol

수율 68.0%

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   기타A 100-ml flask equipped with a stirrer
2. 2
   workup.STIRRINGThe contents were stirred further for 2 hours
3. 3
   기타The resultant reaction mixture
4. 4
   농축was concentrated under reduced pressure
5. 5
   기타the resultant residue was purified by column chromatography on silica gel

실험 절차

A 100-ml flask equipped with a stirrer and dropping funnel was then charged with 16.8 g (280 mmol) of ethanolamine and 15 g of ethanol. While stirring the mixture at 80° C., an ethanol solution of 5.00 g (17.6 mmol) of 1,2-epoxy-2-methyl-3-tetradecyloxypropane was added dropwise over 3 hours. The contents were stirred further for 2 hours. The resultant reaction mixture was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 4.13 g (yield: 68%) of the title compound.

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