반응 #11976

반응 방정식

1-(3,4-Dichloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione

5-amino-1H-pyrazole-3-carboxylic acid

→

5-(3,4-dichloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

수율 90.9%

용매

acetic acid

반응 조건

후처리

1. 1
   온도at reflux for 48 hours
2. 2
   농축The reaction concentrated under reduced pressure
3. 3
   기타the crude product was purified by column chromatography on silica gel

실험 절차

1-(3,4-Dichloro-phenyl)-4,4,4-trifluoro-butane-1,3-dione (1.00 g, 3.51 mmol) and 5-amino-1H-pyrazole-3-carboxylic acid (0.446 g, 3.51 mmoL) in acetic acid (100 mL) was heated at reflux for 48 hours. The reaction concentrated under reduced pressure and the crude product was purified by column chromatography on silica gel to give 5-(3,4-dichloro-phenyl)-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (1.20 g, 90%).

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