반응 #1196870

반응 방정식

8-(3,4-difluorophenyl)-1,4-dioxa-7-spiro[4.5]decene

triethylamine

hydrogen

→

8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decane

용매

toluene acetone

반응 조건

후처리

1. 1
   여과The catalyst was filtered off from the reaction mixture
2. 2
   농축the filtrate was concentrated

실험 절차

A solution of 6.44 g of 8-(3,4-difluorophenyl)-1,4-dioxa-7-spiro[4.5]decene, 1 ml of triethylamine and 125 ml of toluene/acetone (vol. 4:1) was hydrogenated with 1 g of palladium/carbon (10%) at room temperature and normal pressure until the hydrogen uptake came to a standstill. The catalyst was filtered off from the reaction mixture and the filtrate was concentrated. There were obtained 6.30 g of colourless, solid 8-(3,4-difluorophenyl)-1,4-dioxaspiro[4.5]decane.

출처