반응 #11950

반응 방정식

8-Aminoquinoline

potassium carbonate

methyl 4-bromomethylbenzoate

→

title compound

수율 172.4%

Methyl 4-(8-quinolylaminomethyl)benzoate

수율 172.4%

용매

DMF

반응 조건

후처리

1. 1
   농축the reaction solution was concentrated
2. 2
   workup.ADDITIONThe resulting residue was diluted with chloroform and water
3. 3
   workup.ADDITIONwas added
4. 4
   추출The mixture was extracted with chloroform
5. 5
   세척The organic layer was washed with saturated brine
6. 6
   건조dried over anhydrous sodium sulfate
7. 7
   농축concentrated

실험 절차

8-Aminoquinoline (1.26 g) was dissolved in DMF (20 ml), and potassium carbonate (1.2 g) and methyl 4-bromomethylbenzoate (1.0 g) were added. After stirring for 20 hours, the reaction solution was concentrated. The resulting residue was diluted with chloroform and water was added. The mixture was extracted with chloroform. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated to obtain the title compound (2.20 g) as a yellow syrup.

출처