반응 #1195

반응 방정식

ethanolamine

ethanol

ethanol

butyl 12-(2,3-epoxypropoxy)-dodecanate

→

title compound

수율 55.4%

butyl 12-[2-hydroxy-3-(2-hydroxyethylamino)propoxy]dodecanate

수율 55.4%

용매

water

반응 조건

후처리

1. 1
   기타A 100-ml flask equipped with a stirrer
2. 2
   workup.ADDITIONwas added to the reaction mixture
3. 3
   추출followed by extraction with chloroform
4. 4
   농축The resultant chloroform solution was concentrated under reduced pressure
5. 5
   기타the resultant residue was purified by column chromatography on silica gel

실험 절차

A 100-ml flask equipped with a stirrer and dropping funnel was charged with 23.7 g (250 mmol) of ethanolamine and 23.7 g of ethanol. While stirring the mixture at 80° C., an ethanol solution of 8.20 g (25 mmol) of butyl 12-(2,3-epoxypropoxy)-dodecanate was added dropwise over 1 hour. After completion of the reaction, water was added to the reaction mixture, followed by extraction with chloroform. The resultant chloroform solution was concentrated under reduced pressure, and the resultant residue was purified by column chromatography on silica gel, thereby obtaining 5.40 g (yield: 55.4%) of the title compound (Ia-15).

출처