반응 #11918

반응 방정식

8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one

triethylamine hydrochloride

POCl3

→

solid

수율 89.0%

4-Chloro-8-methoxy-2-(2-trifluoromethyl-phenyl)-quinazoline

수율 89.0%

반응 조건

후처리

1. 1
   기타Purification by flash chromatography

실험 절차

Prepared from 8-methoxy-2-(2-trifluoromethyl-phenyl)-3H-quinazolin-4-one (1.0 g, 3.12 mmol), triethylamine hydrochloride (472 mg, 3.43 mmol), and POCl3. Purification by flash chromatography afforded a white solid (89% yield). HPLC-Method A, Rt 4.10 min, (98%), MS (m/z) 258.08 (M+H).

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