반응 #11905

ord-5afd81cea1474aa1b6e2b9885c61c1a1

반응 방정식

O=[N+]([O-])c1ccc(Cl)c(Cl)c1Cl
2,3,4-trichloro-nitro-benzene
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1
4-carbobenzyloxypiperazine-2-carboxylic acid
→
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1c1c([N+](=O)[O-])ccc(Cl)c1Cl
desired product
수율 43.6%
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1c1c([N+](=O)[O-])ccc(Cl)c1Cl
4-Carbobenzyloxy-1-(5,6-Dichloro-2-Nitrophenyl)Piperazine-2-Carboxylic Acid
수율 43.6%

반응물

O=[N+]([O-])c1ccc(Cl)c(Cl)c1Cl
2,3,4-trichloro-nitro-benzene
O=C(O)C1CN(C(=O)OCc2ccccc2)CCN1
4-carbobenzyloxypiperazine-2-carboxylic acid

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

By the same procedure described for Example 7 A, from 0.86 g of 2,3,4-trichloro-nitro-benzene and 1.0 g of 4-carbobenzyloxypiperazine-2-carboxylic acid, there was obtained 0.75 g of the desired product as a brown oil.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07098338B2uspto-grants-2006_08