반응 #11902

반응 방정식

trityl candesartan cilexetil

toluene

methanol

→

candesartan cilexetil

용매

water

반응 조건

후처리

1. 1
   온도was gently refluxed for about 5 h
2. 2
   기타The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. to 60° C.

실험 절차

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), toluene (60 ml), methanol (120 ml), and water (1 ml) was gently refluxed for about 5 h. The reaction progress was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. to 60° C. to obtain viscous oil of candesartan cilexetil as a residue (36.5 g).

출처