반응 #11901

반응 방정식

trityl candesartan cilexetil

toluene

methanol

→

candesartan cilexetil

용매

water

반응 조건

후처리

1. 1
   온도was gently refluxed for about 12 h
2. 2
   기타The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C

실험 절차

A mixture of trityl candesartan cilexetil (20 g, 23.45 mmol), toluene (60 ml), methanol (60 ml), and water (1 ml) was gently refluxed for about 12 h. The reaction was monitored by HPLC. The solution volume was reduced by evaporation under reduced pressure (30 mbar) at a temperature of about 55° C. 60° C. to obtain viscous oil of candesartan cilexetil as a residue (36.5 g).

출처