반응 #1186927

ord-1f53f9a4c0fd400895a2148b226073bf

반응 방정식

Clc1ccc2ncccc2c1
Clc1ccc2ncccc2c1
Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O
Cc1ccc2c(cnn2C2CCCCO
→
Cc1ccc2c(cnn2C2CCCCO2)c1-c1ccc2ncccc2c1
Cc1ccc2c(cnn2C2CCCCO
수율 2.0%

반응물

Clc1ccc2ncccc2c1
Clc1ccc2ncccc2c1
Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O
Cc1ccc2c(cnn2C2CCCCO2)c1B(O)O

시약

Cc1ccccc1P(c1ccccc1C)c1ccccc1C
Cc1ccccc1P(c1ccccc1C)c1ccccc1C
O=C([O-])O.[Na+]
O=C([O-])O.[Na+]
CC(C)(C)c1ccc(-c2ccc(C(C)(C)C)cc2)cc1
CC(C)(C)c1ccc(-c2ccc(C(C)(C)C)
CC(=O)[O-].CC(=O)[O-].[Pd+2]
CC(=O)[O-].CC(=O)[O-].[Pd+2]

용매

CCc1cccc(CC)c1
CCc1cccc(CC)c1
CC#N
CC#N
O
O
Cc1ccccc1
Cc1ccccc1
O
O
CN(C)C=O
CN(C)C=O
CCc1cc(CC)cc(CC)c1
CCc1cc(CC)cc(CC)c1

반응 조건

온도
100°CELSIUS

출처

DOI: 10.1126/science.aap9112Rapid material-sparing screening of 5760 Suzuki-Miyaura coupling reactions