반응 #1180667

반응 방정식

Compound 87-4

[5-(2-{4-[3-(2,2-difluoro-1,3-benzodioxol-5-yl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester

hydrochloric acid

→

product

2-amino-2-(2-{4-[3-(2,2-difluoro-1,3-benzodioxol-5-yl)propoxy]-3-trifluoromethylphenyl}ethyl)propane-1,3-diol hydrochloride

용매

ethanol

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated
2. 2
   세척the residue was washed with diethyl ether

실험 절차

Compound 87-4 (870 mg) was dissolved in ethanol (15 ml), concentrated hydrochloric acid (1.5 ml) was added, and the mixture was stirred at 80° C. for 1.5 hr. The reaction mixture was concentrated, and the residue was washed with diethyl ether to give the object product (510 mg) as a white powder.

출처