반응 #11805

반응 방정식

6-methyl-nicotinic acid methyl ester

2,2′-azobis(2-methyl-proprionitrile)

N-bromosuccinimide

→

title compound

수율 34.1%

6-Bromomethyl-nicotinic acid methyl ester

수율 34.1%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   온도at reflux for 12 hours
2. 2
   온도cooled
3. 3
   농축concentrated in vacuo

실험 절차

To a solution of 6-methyl-nicotinic acid methyl ester (0.54 g, 3.57 mmol) in carbon tetrachloride (10 mL) was added 2,2′-azobis(2-methyl-proprionitrile) (0.030 g, 0.18 mmol) and N-bromosuccinimide (0.703 g, 3.95 mmol). The solution was stirred at reflux for 12 hours, cooled and concentrated in vacuo. Flash chromatography on silica gel provided the title compound (0.28 g).

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