반응 #1178697

반응 방정식

2-Amino-4,5-dimethoxybenzonitrile

ethylenediamine

→

2-(4,5-dihydro-1H-imidazol-2-yl)-4,5-dimethoxyaniline

수율 82.3%

용매

water

반응 조건

후처리

1. 1
   온도The resulting solution was warmed to 40
2. 2
   온도The mixture was heated to 80-90
3. 3
   여과the resulting precipitate was collected by filtration

실험 절차

2-Amino-4,5-dimethoxybenzonitrile (5.0 g, 28 mmol) was added to ethylenediamine (7.9 g, 131 mmol) at room temperature. The resulting solution was warmed to 40., and a catalytic amount of diphosphorus pentasulfide (50 mg) was added. The mixture was heated to 80-90, and the stirring was continued overnight. The reaction mixture was diluted with water, and the resulting precipitate was collected by filtration to give 2-(4,5-dihydro-1H-imidazol-2-yl)-4,5-dimethoxyaniline (5.1 g, 82%) as a solid.

출처