반응 #1178413

반응 방정식

2,2-dimethoxypropane

p-toluenesulfonic acid monohydrate

→

(2,2-dimethyl-[1,3]dioxan-5-yl)-methanol

용매

DMF

반응 조건

후처리

1. 1
   workup.ADDITIONwere added
2. 2
   기타As much solvent as possible was removed in vacuo
3. 3
   workup.DISTILLATIONthe remainder was purified by distillation under vacuum

실험 절차

Triol 3-1 (1 eq.) was dissolved in DMF at a concentration of approximately 0.5 M and 2,2-dimethoxypropane (1.16 eq.) and p-toluenesulfonic acid monohydrate (0.03 eq.) were added. The solution was stirred for one or more days, and was quenched with TEA (0.5 eq.). As much solvent as possible was removed in vacuo and the remainder was purified by distillation under vacuum.

출처