반응 #1178396

반응 방정식

HCl

potassium carbonate

diethyl amine

p-bromobenzyl bromide

→

(p-bromobenzyl)diethyl amine

수율 74.0%

용매

water

water

THF

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   추출The mixture was extracted with 100 ml diethyl ether for three times
3. 3
   건조The diethyl ether solution was dried with anhydrous magnesium sulfate over night
4. 4
   기타the magnesium sulfate was removed by filtration
5. 5
   기타Diethyl ether was evaporated
6. 6
   기타the raw product was purified by a silica gel column

실험 절차

Into a 500 ml round-bottomed flask were added 150 ml THF, 5 ml water, 2.2 g potassium carbonate, 6 ml diethyl amine, and 5 g p-bromobenzyl bromide. The resultant mixture was refluxed for 12 h. The mixture was then cooled to room temperature, into which 6 ml concentrated HCl was added, followed by the addition of 150 ml water. The mixture was extracted with 100 ml diethyl ether for three times. The diethyl ether solution was dried with anhydrous magnesium sulfate over night and then the magnesium sulfate was removed by filtration. Diethyl ether was evaporated and the raw product was purified by a silica gel column using hexane/chloroform mixture (1:1 by volume) as the eluent. (p-bromobenzyl)diethyl amine (BBDA) was obtained in 74% yield (3.6 g).

출처