반응 #1176587

ord-40fc183093f744f5a69812150e3e369b

반응 방정식

CCOC(=O)C(Cl)C(C)=O
Ethyl 2-chloro-acetoacetate
CC(N)=S
thioacetamide
CCOC(=O)C1SC(C)=NC1C
2,4-dimethyl-5-ethoxycarbonyl-thiazoline
CCOS(=O)(=O)c1ccc(C)cc1
ethyl p-toluenesulfonate
→
CCOC(=O)c1sc(C)[n+](CC)c1C.Cc1ccc(S(=O)(=O)[O-])cc1
p-toluenesulfonate
CCOC(=O)c1sc(C)[n+](CC)c1C.Cc1ccc(S(=O)(=O)[O-])cc1
2,4-dimethyl-3-ethyl-5-ethoxycarbonyl-thiazolium p-toluenesulfonate

반응물

CCOC(=O)C(Cl)C(C)=O
Ethyl 2-chloro-acetoacetate
CC(N)=S
thioacetamide
CCOC(=O)C1SC(C)=NC1C
2,4-dimethyl-5-ethoxycarbonyl-thiazoline
CCOS(=O)(=O)c1ccc(C)cc1
ethyl p-toluenesulfonate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Ethyl 2-chloro-acetoacetate is condensed with thioacetamide to 2,4-dimethyl-5-ethoxycarbonyl-thiazoline which is reacted, analogously to Preparation Example 1 A, with ethyl p-toluenesulfonate to give the p-toluenesulfonate of the quaternary ammonium base.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04966828uspto-grants-1990_10