반응 #11764

반응 방정식

4-chloro-2-chloromethyl-1-methoxybenzene

cesium carbonate

thioacetic acid

→

title compound

수율 96.0%

Thioacetic acid S-(5-chloro-2-methoxy-benzyl)ester

수율 96.0%

용매

ethyl acetate

dimethylformamide

반응 조건

후처리

1. 1
   세척washed with water, 5% aqueous sodium hydrogen carbonate, and brine
2. 2
   기타The organic layer was separated
3. 3
   건조dried over sodium sulfate
4. 4
   여과filtered
5. 5
   농축concentrated in vacuo

실험 절차

To a solution of cesium carbonate (0.55 g, 1.70 mmol) in dimethylformamide (13 mL) was added thioacetic acid (0.24 g, 3.14 mmol) followed by addition of 4-chloro-2-chloromethyl-1-methoxybenzene (0.50 g, 2.62 mmol) in one portion. The reaction was stirred in the dark at ambient temperature overnight. The reaction was diluted with ethyl acetate, washed with water, 5% aqueous sodium hydrogen carbonate, and brine. The organic layer was separated, dried over sodium sulfate, filtered and concentrated in vacuo. Chromatography on silica gel gave the title compound (0.58 g).

출처