반응 #1174566

반응 방정식

water

product

2-Chloro-8-(1-hydroxaminoethyl)phenoxathiin

trimethylsilyl isocyanate

→

title compound

N-[1-(8-Chlorophenoxathiin-2-yl)ethyl]-N-hydroxy urea

용매

THF

반응 조건

후처리

1. 1
   workup.STIRRINGwas stirred a further 10 minutes
2. 2
   기타the THF was evaporated
3. 3
   workup.ADDITIONthe residual aqueous suspension diluted with water
4. 4
   여과filtered

실험 절차

To a solution of the product from Step 1 (320 mg, 1.09 mmol) in THF (15 mL) there was added 85% trimethylsilyl isocyanate (295 mg, 2.18 mmol) and the mixture was stirred at room temperature for 45 minutes. After addition of water (5 mL) the mixture was stirred a further 10 minutes, then the THF was evaporated, the residual aqueous suspension diluted with water and filtered to afford the title compound as a white solid, m.p.: dec 173° C. (gassing).

출처