반응 #11727

반응 방정식

chloroacetyl chloride

(2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine

triethylamine

→

title compound

수율 84.9%

2-Chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

수율 84.9%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The resulting reaction mixture
2. 2
   여과The reaction was then filtered through a pad of celite
3. 3
   세척washed with dichloromethane
4. 4
   농축the resulting filtrate was concentrated

실험 절차

To a solution of (2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (2.5 g, 11.2 mmol) in dry dichloromethane (11 mL) at 0° C. was added triethylamine (1.57 mL, 11.2 mmol) followed by chloroacetyl chloride (0.86 mL, 11.2 mmol). The resulting reaction mixture was stirred for 30 minutes. The reaction was then filtered through a pad of celite, washed with dichloromethane and the resulting filtrate was concentrated. Chromatography on silica gel gave the title compound (2.84 g).

출처