반응 #11722

반응 방정식

2-chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

4-chloro-2-nitro-phenol

potassium carbonate

potassium iodide

→

title compound

수율 94.8%

2-(4-Chloro-2-nitro-phenoxy)-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone

수율 94.8%

용매

2-butanone

반응 조건

후처리

1. 1
   온도The reaction was refluxed overnight
2. 2
   온도cooled
3. 3
   농축concentrated in vacuo

실험 절차

To a solution of 2-chloro-1-[4-(4-fluoro-benzyl)-(2R)-2-methyl-piperazin-1-yl]-ethanone (0.40 g, 1.4 mmol) in 2-butanone (14 mL) was added 4-chloro-2-nitro-phenol (0.25 g, 1.4 mmol), potassium carbonate (0.39 g, 2.8 mmol) and potassium iodide (233 mg, 1.4 mmol). The reaction was refluxed overnight, cooled and concentrated in vacuo. Chromatography on silica gel gave the title compound (0.56 g).

출처