반응 #1172

반응 방정식

4-Hydroxypiperidine

Et3N

benzyl chloroformate

CHCl3 MeOH

→

N-Cbz-piperidine

수율 59.2%

용매

CH2Cl2

반응 조건

후처리

1. 1
   workup.ADDITIONwas added

실험 절차

4-Hydroxypiperidine (10.8 g, 107 mmol) and Et3N (17 mL, 123 mmol) in 80 mL of CH2Cl2 was cooled in an ice bath whereupon benzyl chloroformate (16.3 mL, 114 mmol) was added. After stirring 1.5 h at R.T. the mixture was subjected to standard work-up conditions to give 13.9 g (55%) of N-Cbz-piperidine after chromatography (CHCl3 /MeOH; 10:1). [1H]-NMR(CDCl3) consistent with structure.

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