반응 #1171607

반응 방정식

2-methyl-6-phenylpyridine

isophthalaldehyde

→

title compound

3-(2-(6-phenylpyridin-2-yl)ethenyl)benzaldehyde

반응 조건

후처리

1. 1
   기타The resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer
2. 2
   세척was washed with H2O (10 cc), brine and solvent
3. 3
   기타as removed in vacuo
4. 4
   기타The residue was purified by chromatography

실험 절차

A mixture of 2-methyl-6-phenylpyridine (525 mg) (step 2), isophthalaldehyde (630 mg) and dry zinc chloride (40 mg) was heated at 160° C. under N2 for 3 hours. The resulting mixture was partitioned between 25% aqueous NH40Ac (20 cc) and ethyl acetate (20 cc) The organic layer was washed with H2O (10 cc), brine and solvent as removed in vacuo. The residue was purified by chromatography to afford the title compound.

출처