반응 #1171

반응 방정식

4-Piperidinecarboxamide

benzyl bromide

→

N-benzyl-4-piperidinecarboxamide

수율 35.0%

용매

EtOAc

DMSO

반응 조건

후처리

1. 1
   세척washed with 1N aq. HCl, 5N aq. NaOH
2. 2
   건조dried over MgSO4
3. 3
   농축concentrated

실험 절차

4-Piperidinecarboxamide (10.2 g, 78.0 mmol) in DMSO (10 mL) was treated with benzyl bromide (20.0 mL, 168 mmol). The mixture was diluted with EtOAc and washed with 1N aq. HCl, 5N aq. NaOH, dried over MgSO4, and concentrated to give 5.90 g (35%) of N-benzyl-4-piperidinecarboxamide. [1H]-NMR(CDCl3) consistent with structure.

출처