반응 #11696

반응 방정식

(S)-4-(t-butyloxycarbonylamino)-2,3,4,5-tetrahydro-2-benzazepin-3(1H)-one

hydrogen chloride

→

(S)-4-amino-2,3,4,5-tetrahydro-2-benzazepin-3(1H)-one hydrochloride

용매

diethyl ether

반응 조건

후처리

1. 1
   기타A precipitate slowly formed
2. 2
   기타was evaporated under vacuum
3. 3
   기타evaporated

실험 절차

(S)-4-(t-butyloxycarbonylamino)-2,3,4,5-tetrahydro-2-benzazepin-3(1H)-one (276 mg) was dissolved in 2 M hydrogen chloride in diethyl ether solution (25 mL) at room temperature. A precipitate slowly formed. After 16 h stirring the solvent was evaporated under vacuum. The residue was twice taken up in toluene (10 mL) and evaporated to provide (S)-4-amino-2,3,4,5-tetrahydro-2-benzazepin-3(1H)-one hydrochloride, which was used directly in the next step.

출처