반응 #1168430

반응 방정식

HCl

Methyl 2-(aminosulfonyl)-1-methyl-1H-pyrrole-3-carboxylate

phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate

DBU

→

title compound

수율 73.5%

Methyl 2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin -2-yl)amino]carbonyl]amino]sulfonyl]-1-methyl-1H-pyrrole-3-carboxylate

수율 73.5%

용매

water

acetonitrile

반응 조건

후처리

1. 1
   여과the resulting precipitate was collected by filtration
2. 2
   세척rinsed successively with water and ether
3. 3
   기타dried

실험 절차

Methyl 2-(aminosulfonyl)-1-methyl-1H-pyrrole-3-carboxylate (0.10 g, 0.46 mmol) and 0.13 g (0.50 mmol) of phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate were combined in 2 mL of acetonitrile and 0.075 mL of DBU was added and the resulting amber solution was stirred at ambient temperature for 30 min. The reaction mixture was diluted with 15 mL of water and acidified with 0.5 mL 1N HCl and the resulting precipitate was collected by filtration and rinsed successively with water and ether, then dried to afford 0.13 g of the title compound as a white solid, m.p. 189°-190° C. (dec).

출처