반응 #1167

반응 방정식

lithium aluminum hydride

cis-2-benzyl-7-methoxy-1,3,3a,9b-tetrahydrobenzopyrano[3,4-c]pyrrol-4-one

→

expected product

cis-1-Benzyl-3-hydroxymethyl-4-(2-hydroxy-4-methoxyphenyl)pyrrolidine

용매

THF

반응 조건

후처리

1. 1
   기타described in Preparation G, at +5° C
2. 2
   온도The reaction medium is maintained at +10° C. for one hour
3. 3
   여과is filtered on Celite
4. 4
   기타The organic phase is dried
5. 5
   기타after evaporation

실험 절차

To 230 mmol of lithium aluminum hydride in 800 ml of THF, under a nitrogen atmosphere, are added 180 mmol of cis-2-benzyl-7-methoxy-1,3,3a,9b-tetrahydrobenzopyrano[3,4-c]pyrrol-4-one, described in Preparation G, at +5° C. The reaction medium is maintained at +10° C. for one hour before being hydrolyzed, and is filtered on Celite. The organic phase is dried and, after evaporation, gives the expected product.

출처