반응 #1166473

반응 방정식

2-(2-hydroxyethyl)-3-methylthiazole

triethylamine

acryloyl chloride

→

dark brown liquid

수율 82.0%

2-(Acryloyloxyethyl)-3-methylthiazole

수율 82.0%

용매

chloroform

반응 조건

후처리

1. 1
   기타A one liter, three necked flask was equipped with overhead stirrer
2. 2
   추출The reaction mixture was extracted with NaCl(aq.), NH4OH(10%), NaCl(aq.)
3. 3
   건조dried over MgSO4
4. 4
   기타The chloroform was evaporated with a rotoevaporator

실험 절차

A one liter, three necked flask was equipped with overhead stirrer, nitrogen atmosphere and an addition funnel. The flask was charged with 100 g of 2-(2-hydroxyethyl)-3-methylthiazole (0.70 mol.), 71 g of triethylamine (0.70 mol.), 500 g of chloroform and 3 g of phenothiazine. Next, 63 g of acryloyl chloride (0.70 mol.) was slowly added to the reaction over 1.5 hour via the addition funnel. The reaction was stirred for 2 hours at room temperature. The reaction mixture was extracted with NaCl(aq.), NH4OH(10%), NaCl(aq.) and dried over MgSO4. The chloroform was evaporated with a rotoevaporator to yield 113 g (82%) of a dark brown liquid. The compound was confirmed by IR and 13C NMR.

출처