반응 #1166464

반응 방정식

4-butoxy-3, 7-diacetoxy-2H-l-benzopyran-2-one

sodium methoxide

→

title compound

수율 85.0%

3-acetoxy-4-butoxy-7-hydroxy-2H-1-benzopyran-2-one

수율 85.0%

용매

methanol

반응 조건

후처리

1. 1
   workup.ADDITIONThen 22.36 g of Amberlyst-15 was added
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 1 hour
3. 3
   여과Amberlyst-15 was filtered off
4. 4
   농축the filtrate was concentrated under reduced pressure
5. 5
   기타to give a crystalline product
6. 6
   기타The product was reprecipitated from tertahydrofuran and hexane

실험 절차

To a mixture of 17.31 g of 4-butoxy-3, 7-diacetoxy-2H-l-benzopyran-2-one (51.79 mmol) in 170 ml of methanol was added 2.66 g of sodium methoxide (49.20 mmol) and the reaction mixture was stirred at room temperature for 3 hours. Then 22.36 g of Amberlyst-15 was added, and the mixture was stirred at room temperature for 1 hour. Amberlyst-15 was filtered off and the filtrate was concentrated under reduced pressure to give a crystalline product. The product was reprecipitated from tertahydrofuran and hexane to give 12.87 g of the title compound. (yield=85%)

출처