반응 #1166

반응 방정식

sodium chloride

isopropyl alcohol

lithium aluminum hydride

methyl [trans-1-benzyl-4-(2-methoxyphenyl)pyrrolidin-3-yl]carboxylate

→

expected product

trans-1-Benzyl-3-hydroxymethyl-4-(2-methoxyphenyl)pyrrolidine

용매

THF

tetrahydrofuran

반응 조건

후처리

1. 1
   기타described in Preparation A)
2. 2
   workup.STIRRINGThe mixture is stirred slowly at room temperature
3. 3
   여과After filtration and evaporation of the solvents

실험 절차

To 560 mmol of lithium aluminum hydride in 800 ml of tetrahydrofuran (THF), under a nitrogen atmosphere and at 5° C., are added 225 mmol of methyl [trans-1-benzyl-4-(2-methoxyphenyl)pyrrolidin-3-yl]carboxylate (described in Preparation A) dissolved in 500 ml of THF. After stirring for 1 hour at 5° C., 139 ml of isopropyl alcohol are added slowly to the above mixture, followed by 85.2 ml of saturated sodium chloride solution. The mixture is stirred slowly at room temperature. After filtration and evaporation of the solvents, the expected product is obtained.

출처